Randomised comparative study of ceftriaxone and spectinomycin in gonorrhoea.
نویسندگان
چکیده
From 26 April to 30 June 1983 a total of 200 men with uncomplicated gonococcal urethritis were randomly treated with either 2 g spectinomycin or 250 mg ceftriaxone, both administered intramuscularly. Of 197 isolates tested for the presence of the enzyme beta lactamase, 91 (46.2%) were positive (PPNG) and 106 (53.8%) were non-PPNG strains. All 93 patients treated with spectinomycin and followed up and 97 treated with ceftriaxone and followed up were cured. Ceftriaxone 250 mg administered by intramuscular injection is highly effective in treating gonococcal infections caused by both PPNG and non-PPNG strains and is an appropriate alternative to spectinomycin.
منابع مشابه
Prescription of Antibiotics to Treat Gonorrhoea in General Practice in Flanders 2009–2013: A Registry-Based Retrospective Cohort Study
BACKGROUND General practitioners (GPs) as a group have been identified as playing an important role in gonorrhoea management in Flanders. Belgian guidelines recommended ceftriaxone or alternatively spectinomycin from 2008 onwards and azithromycin combination therapy since 2012. OBJECTIVES This study investigates to which extent contemporary gonorrhoea treatment guidelines were followed. MET...
متن کاملEfficacy and safety of ceftriaxone for uncomplicated gonorrhoea: a meta-analysis of randomized controlled trials.
We conducted a systematic review and meta-analysis of ceftriaxone for treatment of uncomplicated gonorrhoea compared with four other antibiotics. Thirteen randomized controlled trials (RCTs) totalling treatment of 2557 patients with uncomplicated gonorrhoea were included. Statistically significant differences were observed in side-effects, which were increased after ceftriaxone 250 mg versus ce...
متن کاملClinical efficacy of the various drugs used in the treatment of gonorrhoeae.
BACKGROUND Gonorrhoea is a purulent inflammation of mucus membrane of the genital tract and is a highly contagious sexually transmitted disease (STD) caused by the bacterium Neisseria gonorrhoae. Both men and women can be infected through a variety of sexual contact behaviours including vaginal, anal or oral intercourses. This comparative study was carried out in New Gulail Polyclinic Jeddah, K...
متن کامل[Spectinomycin in the treatment of gonorrhea].
To the editor: We have read with interest the recent paper by Kubanova et al. in which they recommend the use of spectinomycin in case of difficulty to access ceftriaxone or in the presence of severe beta-lactam antimicrobial allergy [1]. Although we agree with most of the conclusions we would like to warn about the potential risks in cases of pharyngeal gonorrhoea. Spectinomycin is an aminogly...
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BACKGROUND The Hungarian national guidelines for the treatment of gonorrhoea were published in 2002 but are now widely considered to be outdated. Improved knowledge is needed with respect to the epidemiology and antimicrobial susceptibility of Neisseria gonorrhoeae strains currently circulating in Hungary not least for the construction of updated local recommendations for treating gonorrhoea. E...
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عنوان ژورنال:
- Genitourinary medicine
دوره 61 2 شماره
صفحات -
تاریخ انتشار 1985